NITRIC-OXIDE DESTROYS ZINC-SULFUR CLUSTERS INDUCING ZINC RELEASE FROMMETALLOTHIONEIN AND INHIBITION OF THE ZINC FINGER-TYPE YEAST TRANSCRIPTION ACTIVATOR LAC9

Authors
KRONCKE KD FEHSEL K SCHMIDT T ZENKE FT DASTING I WESENER JR BETTERMANN H BREUNIG KD KOLBBACHOFEN V
Citation
Kd. Kroncke et al., NITRIC-OXIDE DESTROYS ZINC-SULFUR CLUSTERS INDUCING ZINC RELEASE FROMMETALLOTHIONEIN AND INHIBITION OF THE ZINC FINGER-TYPE YEAST TRANSCRIPTION ACTIVATOR LAC9, Biochemical and biophysical research communications, 200(2), 1994, pp. 1105-1110
Citations number
27
Categorie Soggetti
Biology,Biophysics
Journal title
Biochemical and biophysical research communications → ACNP
ISSN journal
0006291X
Volume
200
Issue
2
Year of publication
1994
Pages
1105 - 1110
Database
ISI
SICI code
0006-291X(1994)200:2<1105:NDZCIZ>2.0.ZU;2-#
Abstract
Nitric oxide, generated from S-nitrosocysteine or applied as gas media tes metal ion release from the Zn2+/Cd2+-complexing protein metallothi onein via oxidation of SH-groups. Time-dependent S-nitrosylation and s ubsequent disulfide formation of metallothionein are demonstrated. Fur thermore, nitric oxide inhibits DNA binding activity of the yeast tran scription factor LAC9 containing a zinc finger like DNA binding domain . These results show that nitric oxide interacts with and destroys zin c-sulfur clusters in proteins. (C) 1994 Academic Press, Inc.