EICOSAPENTAENOIC ACID ENHANCES INTRACELLULAR FREE CALCIUM IN CULTUREDHUMAN ENDOTHELIAL-CELLS

Authors
OKUDA Y EZURE M TSUKAHARA K SAWADA T MIZUTANI M KATORI T BANNAI C YAMASHITA K
Citation
Y. Okuda et al., EICOSAPENTAENOIC ACID ENHANCES INTRACELLULAR FREE CALCIUM IN CULTUREDHUMAN ENDOTHELIAL-CELLS, Biochemical medicine and metabolic biology, 51(2), 1994, pp. 166-168
Citations number
8
Categorie Soggetti
Medicine, Research & Experimental",Biology
Journal title
Biochemical medicine and metabolic biology → ACNP
ISSN journal
08854505
Volume
51
Issue
2
Year of publication
1994
Pages
166 - 168
Database
ISI
SICI code
0885-4505(1994)51:2<166:EAEIFC>2.0.ZU;2-0
Abstract
Eicosapentaenoic acid (EPA) caused elevations of intracellular free Ca 2+ concentration ([Ca2+](i)) measured by fura-2 fluorescence in cultur ed human endothelial cells. The EPA induced increase in [Ca2+](i) coul d still be observed when either cyclooxygenase or lipoxygenase inhibit ors were added. These results suggest that EPA itself rather than its metabolites has direct effects on intracellular Ca2+ mobilization, cau sing the elevation of [Ca2+](i). (C) 1994 Academic Press, Inc.