EFFECT OF ENTERUED(R) ADMINISTRATION ON T HE INTESTINAL-ABSORPTION OFORALLY-ACTIVE CEFEM ANTIBIOTICS

The effect of simultaneous administration of Enterued (R), an elementa l diet, which is composed of oligopeptides (egg white hydrolyzate), on the orally active cefems was investigated. Ceftibuten (CETB) administ ered together with Enterued (R) to man was excreted slower in the urin e. AUC from the plasma concentrations of CETB after the oral administr ation with Enterued (R) was markedly decreased compared to that withou t Enterued (R) in rat. In contrast, neither urinary excretion of cepha lexin (CEX) in man nor the AUC from the plasma profile of CEX in rat w as changed by Enterued (R). Furthermore, the disappearance, tissue acc umulation, net absorption of CETB from the rat jejunal loop were signi ficantly inhibited by Enterued (R). However, the net absorption of CEX has no alternation in the presence of Enterued (R), although the appa rent disappearance decreased on the basis of the diminishment of tissu e accumulation. Additionally, Hepan ED (R), which is an elementary die t composed of amino acids, and the mineral solution containing neither peptides nor vitamins have also exhibited the decreasing effect on th e CETB absorption behaviour. These results suggested that the inhibito ry effects of Enterued (R) on the absorption of these antibiotics were not due to the inhibition of peptide-transport systems.