ANTITUMOR-PROMOTING ACTIVITIES OF KAMPO P RESCRIPTIONS .2. INHIBITORYEFFECTS OF SHOUSEIRYU-TO ON 2-STAGE CARCINOGENESIS OF MOUSE SKIN TUMORS AND MOUSE PULMONARY TUMORS

Authors
KONOSHIMA T TAKASAKI M KOZUKA M TOKUDA H
Citation
T. Konoshima et al., ANTITUMOR-PROMOTING ACTIVITIES OF KAMPO P RESCRIPTIONS .2. INHIBITORYEFFECTS OF SHOUSEIRYU-TO ON 2-STAGE CARCINOGENESIS OF MOUSE SKIN TUMORS AND MOUSE PULMONARY TUMORS, Yakugaku zasshi, 114(4), 1994, pp. 248-256
Citations number
19
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Yakugaku zasshi → ACNP
ISSN journal
00316903
Volume
114
Issue
4
Year of publication
1994
Pages
248 - 256
Database
ISI
SICI code
0031-6903(1994)114:4<248:AAOKPR>2.0.ZU;2-4
Abstract
To search for possible anti-tumor promoters, we carried out a primary screening of fourteen kampo prescriptions utilizing their possible inh ibitory effects on the Epstein-Barr virus early antigen (EBV-EA) activ ation which is induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). In these prescriptions, shouseiryu-to exhibited the most significant i nhibitory effect on the EBV-EA activation. Furthermore, two-stage carc inogenesis of mouse skin tumors induced by 7,12-dimethylbenz[a]anthrac ene (DMBA) and TPA, and mouse pulmonary tumors induced by 4-nitroquino line-N-oxide (4NQO) and glycerol were strongly inhibited by shouseiryu -to.