La. Lampson et al., ENHANCED T-CELL MIGRATION TO SITES OF MICROSCOPIC CNS DISEASE - COMPLEMENTARY TREATMENTS EVALUATED BY 2-D AND 3-D IMAGE-ANALYSIS, Brain pathology, 4(2), 1994, pp. 125-134
Novel therapies are being developed to attack tumour or other abnormal
cells within the brain. A general problem is the need for delivery to
sites of microscopic disease. Leukocytes offer an attractive solution
; they are able to both move through tissue and recognize abnormal tar
gets. Leukocytes may act as effecters, or as vehicles for drugs, retro
viral vectors or other agents. Here, we illustrate complementary ways
of enhancing leukocyte migration to sites of microscopic central nervo
us system (CNS) disease. Enhanced T cell migration to sites of dissemi
nated tumour is used as the example. Computer-assisted image analysis
is used to evaluate migration patterns in 2 and 3 dimensions. Shared r
egulatory features in the migration of tumour and responding cells, an
d the opportunities and questions they imply, are discussed.