ENHANCED T-CELL MIGRATION TO SITES OF MICROSCOPIC CNS DISEASE - COMPLEMENTARY TREATMENTS EVALUATED BY 2-D AND 3-D IMAGE-ANALYSIS

Novel therapies are being developed to attack tumour or other abnormal cells within the brain. A general problem is the need for delivery to sites of microscopic disease. Leukocytes offer an attractive solution ; they are able to both move through tissue and recognize abnormal tar gets. Leukocytes may act as effecters, or as vehicles for drugs, retro viral vectors or other agents. Here, we illustrate complementary ways of enhancing leukocyte migration to sites of microscopic central nervo us system (CNS) disease. Enhanced T cell migration to sites of dissemi nated tumour is used as the example. Computer-assisted image analysis is used to evaluate migration patterns in 2 and 3 dimensions. Shared r egulatory features in the migration of tumour and responding cells, an d the opportunities and questions they imply, are discussed.