INTRAVENOUS INDUCTION OF GENERAL-ANESTHESIA WITH ELTANOLONE IN CHILDREN 6-15 YEARS OF AGE

Background: Eltanolone is a short-acting intravenous anaesthetic, form ulated as an oil-water emulsion. The aim of the present study was to e stimate the anaesthetic dose (ED(50)) for induction in children 6-10 a nd 11-15 years of age and to collect safety data. Methods: Forty-nine unpremedicated children, all ASA I or II, divided in one pilot-study g roup, with 5 children 6-15 years and two main study groups, 6-10 and 1 1-15 years of age, were studied. The first patient in each study group was given 0.86 mg/kg of eltanolone iv over 20 s. Fifty s after inject ion the chin was gently lifted to 'the sniffing position' and the anae sthesia mask was placed over the face. Induction was considered satisf actory if there was no gross movement, coughing or response to verbal command during the following 15 s. The dose selected for the next pati ent was based on the observed response: if induction was not classifie d as satisfactory the dose was increased by a factor of 20%, otherwise it was decreased by the same factor. ED(50) was estimated as describe d by Dixon and Massey. Results: In children 6-10 years of age ED(50) w as 0.68 (0.49-0.92; 95% confidence limits) mg/kg and in children 11-15 years of age 0.53 (0.41-0.68) mg/kg. No child showed sign of pain on injection. One patient developed urticaria and 15 patients had transie nt rash after induction. Two patients (both responders receiving 0.86 and 0.40 mg/kg respectively) had apnoea lasting more than 15 s. Involu ntary movements occurred in one patient. Conclusion: The ED(50) of elt anolone for induction of anaesthesia in unpremedicated children 6-10 y ears of age was 0.68 mg/kg and in children 11-15 years of age 0.53 mg/ kg. The findings suggest that an induction dose for children 6-15 year s of age of about 1 mg/kg would be adequate in most cases. No serious adverse events were recorded. However, the drug has subsequently been withdrawn from further investigation due to an unacceptable incidence of rash and urticaria. (C) Acta Anaesthesiologica Scandinavica 41 (199 7).