Lm. Vaughan et Cy. Poon, STABILITY OF CEFTAZIDIME AND VANCOMYCIN ALONE AND IN COMBINATION IN HEPARINIZED AND NONHEPARINIZED PERITONEAL-DIALYSIS SOLUTION, The Annals of pharmacotherapy, 28(5), 1994, pp. 572-576
OBJECTIVE: To examine the stability of ceftazidime, vancomycin, and he
parin, alone and in combination, in dialysis solution over six days at
three temperatures. DESIGN: Nine 250-mL Dianeal PD-2 dextrose 1.5% ba
gs were prepared with ceftazidime, vancomycin, and heparin alone and i
n combination at set concentrations of 100 mug/mL, 50 mug/mL, and 1 un
it/mL, respectively. Three bags of each mixture were stored at 4, 25,
and 37-degrees-C. Duplicate samples for analysis were removed from eac
h bag at the following time points: premix, 0, 12, 24, 48, 72, 96, 120
, and 144 hours. MAIN OUTCOME MEASURES: Each sample was examined visua
lly for signs of cloudiness and precipitation. Each sample was analyze
d by stability-indicating HPLC assay for ceftazidime and vancomycin, w
ith stability defined as less than 10 percent degradation of drug over
time. RESULTS: No color change or precipitation was observed in any b
ag. Vancomycin with or without heparin was stable for 5-6 days at 4, 2
5, and 37-degrees-C. Ceftazidime with and without heparin was stable f
or 6 days at 4-degrees-C, 4 days at 25-degrees-C, and less than 12 hou
rs at 37-degrees-C. Vancomycin plus ceftazidime with and without hepar
in was stable for 6 days at 4-degrees-C and 25-degrees-C, and 4-5 days
at 37-degrees-C. Ceftazidime plus vancomycin with or without heparin
was stable for 6 days at 4-degrees-C, 2-3 days at 25-degrees-C, and 12
hours at 37-degrees-C. CONCLUSIONS: Bulk preparations of ceftazidime
and vancomycin, alone and in combination and with or without heparin i
n Dianeal PD dextrose 1.5% solution, are sufficiently stable for use u
p to 6 days under refrigeration or 48 hours at room temperature.