PRENATAL EXPOSURE TO COCAINE - EFFECTS ON AGGRESSION IN SPRAGUE-DAWLEY RATS

Social/aggressive behavior in adult rat offspring (beginning at postna tal Day 180) prenatally exposed to saline, cocaine, or amfonelic acid (AFA) was examined. Pregnant rats received injections of 15 mg/kg of c ocaine, of 0.9% saline twice daily, s.c., or on 2 consecutive days at 4-day intervals, or 1.5 mg/kg amfonelic acid daily throughout gestatio nal Days 1-20. Frequency, duration, and latency of 11 social/aggressiv e behaviors were recorded for two 15-min sessions during which a small er male intruder replaced an ovariectomized