TN924, A CHROMOSOME-BORNE TRANSPOSON ENCODING HIGH-LEVEL GENTAMICIN RESISTANCE IN ENTEROCOCCUS-FAECALIS

Authors
THAL LA CHOW JW CLEWELL DB ZERVOS MJ
Citation
La. Thal et al., TN924, A CHROMOSOME-BORNE TRANSPOSON ENCODING HIGH-LEVEL GENTAMICIN RESISTANCE IN ENTEROCOCCUS-FAECALIS, Antimicrobial agents and chemotherapy, 38(5), 1994, pp. 1152-1156
Citations number
31
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
38
Issue
5
Year of publication
1994
Pages
1152 - 1156
Database
ISI
SICI code
0066-4804(1994)38:5<1152:TACTEH>2.0.ZU;2-3
Abstract
Enterococcus faecalis SF350 is a clinical isolate from Winnipeg, Canad a, with high-level (MIC > 2,000 mu g/ml) gentamicin resistance. The ge netic determinant for gentamicin resistance was located on the chromos ome of SF350 and could be mobilized by a coresident conjugative plasmi d, pYN120. Genetic and physical analyses showed that the gentamicin re sistance determinant was located on a 27-kb transposable element which was designated Tn924.