IN-VITRO ACTIVITIES OF FUROQUINOLINE AND ACRIDONE ALKALOIDS AGAINST PLASMODIUM-FALCIPARUM

Authors
BASCO LK MITAKU S SKALTSOUNIS AL RAVELOMANANTSOA N TILLEQUIN F KOCH M LEBRAS J
Citation
Lk. Basco et al., IN-VITRO ACTIVITIES OF FUROQUINOLINE AND ACRIDONE ALKALOIDS AGAINST PLASMODIUM-FALCIPARUM, Antimicrobial agents and chemotherapy, 38(5), 1994, pp. 1169-1171
Citations number
18
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
38
Issue
5
Year of publication
1994
Pages
1169 - 1171
Database
ISI
SICI code
0066-4804(1994)38:5<1169:IAOFAA>2.0.ZU;2-M
Abstract
The in vitro activities of furo[2,3b]quinoline and acridone alkaloids against Plasmodium falciparum were evaluated by an isotopic semimicrot est. A pyran ring in the furoquinoline nucleus and 2-O-pyranoglycoside and 2-nitro substituents in the acridone nucleus improved the antimal arial activities of the compounds. These findings provide a clue for f urther chemical modifications.