RIFAMPIN FOR THERAPY OF EXPERIMENTAL PNEUMOCOCCAL MENINGITIS IN RABBITS

Authors
NAU R KAYE K SACHDEVA M SANDE ER TAUBER MG
Citation
R. Nau et al., RIFAMPIN FOR THERAPY OF EXPERIMENTAL PNEUMOCOCCAL MENINGITIS IN RABBITS, Antimicrobial agents and chemotherapy, 38(5), 1994, pp. 1186-1189
Citations number
23
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
38
Issue
5
Year of publication
1994
Pages
1186 - 1189
Database
ISI
SICI code
0066-4804(1994)38:5<1186:RFTOEP>2.0.ZU;2-P
Abstract
Rifampin at a maximally effective dose was less active than ceftriaxon e (both drugs at 10 mg/kg of body weight.h) in a rabbit model of pneum ococcal meningitis (Delta log(10) CFU/ml.h, -0.40 +/- 0.13 versus -0.7 7 +/- 0.18; P < 0.01). The bactericidal activity of rifampin decreased at concentrations in cerebrospinal fluid greater than those that are clinically achievable, and use of rifampin in combination with ofloxac in had no synergistic or additive effect.