USE OF SPECIFIC POLYCLONAL ANTIBODIES FOR SITE-SPECIFIC DRUG TARGETING TO MALARIA-INFECTED ERYTHROCYTES IN-VIVO

Authors
SINGH AM OWAIS M VARSHNEY GC
Citation
Am. Singh et al., USE OF SPECIFIC POLYCLONAL ANTIBODIES FOR SITE-SPECIFIC DRUG TARGETING TO MALARIA-INFECTED ERYTHROCYTES IN-VIVO, Indian Journal of Biochemistry & Biophysics, 30(6), 1993, pp. 411-413
Citations number
13
Categorie Soggetti
Biophysics,Biology
Journal title
Indian Journal of Biochemistry & Biophysics → ACNP
ISSN journal
03011208
Volume
30
Issue
6
Year of publication
1993
Pages
411 - 413
Database
ISI
SICI code
0301-1208(1993)30:6<411:UOSPAF>2.0.ZU;2-7
Abstract
The possibility of using specific polyclonal antibodies for effective site specific drug targeting to malaria infected erythrocytes has been examined. For this purpose, rabbit polyclonal antiserum was raised ag ainst Plasmodium berghei infected mouse erythrocytes (IRBC) and extens ively absorbed with normal erythrocytes (NRBC). Absorbed antiserum spe cifically recognized IRBC. F(ab')(2)-fragments of these antibodies wer e coupled to chloroquine (chq) laden liposomes. These immunoliposomes when tested in vivo significantly suppressed malarial infection in mic e.