Wb. Lawson et Cn. Karson, CLINICAL CORRELATES OF BODY-WEIGHT CHANGES IN SCHIZOPHRENIA, The Journal of neuropsychiatry and clinical neurosciences, 6(2), 1994, pp. 187-188
Body weight was examined in chronic schizophrenic patients. Underweigh
t medicated patients had normal ventricular brain ratios (VBRs) on CT.
Overweight patients had both normal and abnormal VBRs. Weight decreas
ed during neuroleptic withdrawal; caloric intake and weight increased
when neuroleptics were reinstituted. Weight gain on neuroleptics corre
lated with symptom improvement independent of VBR or gender. Weight ch
anges and psychosis in schizophrenia may be mediated by similar neuroc
hemical systems.