ACETYL SALICYLIC-ACID ALLEVIATES INCREASED SUSCEPTIBILITY TO THROMBOSIS IN PIAL MICROVESSELS OF DEHYDRATED MICE

Effect of water deprivation for 1, 2 and 3 days, on blood parameters a nd photochemically-induced thrombosis in pial microvessels of the mous e were investigated. Blood data of dehydrated mice confirmed hemoconce ntration with significant increases in urea, total proteins and choles terol. The time required for the first platelet aggregate to appear an d time to full occlusion in pial arterioles were significantly shorter in dehydrated mice than in control, thus suggesting an increased susc eptibility to cerebrovascular thrombosis. The effect of acetyl salicyl ic acid (ASA), 100 mg/kg (i.p.), in alleviating the accelerated thromb osis in dehydrated mice was also investigated. Mice were deprived of d rinking water for a 24-hr period prior to the injection of ASA and the photochemical aggregation procedure. Acetyl salicylic acid significan tly prolonged both time to platelet aggregation and to full occlusion of the vessel in dehydrated mice, thus indicating a protective effect.