ENHANCEMENT OF MESSENGER-RNA SYNTHESIS FROM MAREKS-DISEASE VIRUS GENOME IN THE LYMPHOBLASTOID CELL-LINE, MDCC-MSB1, BY 5-AZACYTIDINE

Authors
HAYASHI M FURUICHI T REN S ISOGAI E NONOYAMA M NAMIOKA S
Citation
M. Hayashi et al., ENHANCEMENT OF MESSENGER-RNA SYNTHESIS FROM MAREKS-DISEASE VIRUS GENOME IN THE LYMPHOBLASTOID CELL-LINE, MDCC-MSB1, BY 5-AZACYTIDINE, Journal of veterinary medical science, 56(2), 1994, pp. 287-291
Citations number
32
Categorie Soggetti
Veterinary Sciences
Journal title
Journal of veterinary medical science → ACNP
ISSN journal
09167250
Volume
56
Issue
2
Year of publication
1994
Pages
287 - 291
Database
ISI
SICI code
0916-7250(1994)56:2<287:EOMSFM>2.0.ZU;2-A
Abstract
Marek's disease virus (MDV) DNA in latently infected lymphoblastoid ce ll lines is considerably methylated. A treatment of the MDV-derived ly mphoblastoid cell line, MDCC-MSB1 (MSB1), with 5-azacytidine (5-AzC) r esulted in a hypomethylation of MDV DNA and an increase in mRNA from c ertain portions of the MDV DNA. These results suggest methylation of M DV DNA as being one of the factors associated with a repression of tra nscription of MDV DNA in the lymphoblastoid cell line, MSB1.