AUTOMAT - A NOVEL SOFTWARE SYSTEM FOR THE SYSTEMATIC SEARCH FOR PROTEIN (OR DNA) SIMILARITIES WITH A NOTABLE APPLICATION TO AUTOIMMUNE-DISEASES AND AIDS

Authors
CANTALLOUBE H NAHUM C ACHOUR A LEHNER T CALLEBAUT I BURNY A BIZZINI B MORNON JP ZAGURY D ZAGURY JF
Citation
H. Cantalloube et al., AUTOMAT - A NOVEL SOFTWARE SYSTEM FOR THE SYSTEMATIC SEARCH FOR PROTEIN (OR DNA) SIMILARITIES WITH A NOTABLE APPLICATION TO AUTOIMMUNE-DISEASES AND AIDS, Computer applications in the biosciences, 10(2), 1994, pp. 153-161
Citations number
10
Categorie Soggetti
Mathematical Methods, Biology & Medicine","Computer Sciences, Special Topics","Computer Science Interdisciplinary Applications","Biology Miscellaneous
Journal title
Computer applications in the biosciences → ACNP
ISSN journal
02667061
Volume
10
Issue
2
Year of publication
1994
Pages
153 - 161
Database
ISI
SICI code
0266-7061(1994)10:2<153:A-ANSS>2.0.ZU;2-K
Abstract
Automat is a novel program which finds exhaustively all the oligopepti de segments shared by a given protein of any size with the proteins of a whole databank. It allows the user to collect statistics on the com position of the sequence studied in reference to the databank used. We present here the rationale and the algorithm underlying this powerful software. Besides its immediate interest for identifying efficiently similarities between proteins (or DNAs), biological applications of th is software have already been described in the case of HIV-1 viral pro teins, and Automat should prove useful also for studying more generall y autoimmune diseases.