THE EFFECT OF EPHEDRINE PLUS CAFFEINE ON PLASMA-LIPIDS AND LIPOPROTEINS DURING A 4.2 MJ DAY DIET/

The effect of treatment with a combination of ephedrine and caffeine d uring eight weeks' energy restriction (4.2 MJ/day) on the fasting plas ma lipid profile was studied in obese women. Thirty-two women were ran domly assigned to either ephedrine 20 mg plus caffeine 200 mg (EC) or placebo three times per day. Weight loss (7.8 +/- 0.63 kg) and loss of fat mass (6.2 +/- 0.49 kg) did not differ significantly between the t wo groups. Total cholesterol concentration declined from baseline to w eek 8 (0.58 +/- 0.13 mmol/l) with no significant difference between th e two groups. HDL-cholesterol concentration was decreased by 0.14 +/- 0.03 mmol/l at week 4 and week 8 in the placebo group (P < 0.05) but r emained unchanged in the EC group. No effect of dieting was seen on pl asma triglyceride concentration in the placebo group but a decrease wa s observed in the EC group at week 8. It is suggested that EC combinat ions abolish the decline in HDL-cholesterol during active weight loss due to the beta-agonistic properties of ephedrine.