K. Okuno et al., A NEW CULTIVATION SYSTEM OPERATED UNDER A SUPER HIGH MAGNETIC-FIELD, Journal of fermentation and bioengineering, 77(4), 1994, pp. 453-456
A new cultivation system which operates under a super high magnetic fi
eld in the range of 0.5 to 7 Tesla was developed. In this reactor syst
em, the effects of a high magnetic field on various biological reactio
ns could be investigated not only under a homogeneous high magnetic fi
eld, but also under a gradient magnetic held. The maximum magnetic fie
ld gradient is 23 Tesla/m. Since the superconductive magnet was design
ed so as to significantly reduce the evaporation rates of liquid heliu
m and nitrogen, operation is virtually maintenance-free compared with
that in conventional superconductive magnets. The temperature of the r
eactor is controllable within the range of 10 to 70 degrees C (deviati
ons of +/- 0.1 degrees C). When Escherichia coil B cells were grown at
37 degrees C, total cell number during the stationary phase was 70% h
igher under homogeneous 7 Tesla conditions than in the geomagnetic fie
ld. A three fold larger cell number was detected in a gradient magneti
c fields between 5 and 6 Tesla.