THE INFLUENCE OF 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN ON DIFFUSION RATESAND TRANSDERMAL DELIVERY OF HYDROCORTISONE

Authors
LOFTSSON T FRIORIKSDOTTIR H INGVARSDOTTIR G JONSDOTTIR B SIGUROARDOTTIR AM
Citation
T. Loftsson et al., THE INFLUENCE OF 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN ON DIFFUSION RATESAND TRANSDERMAL DELIVERY OF HYDROCORTISONE, Drug development and industrial pharmacy, 20(9), 1994, pp. 1699-1708
Citations number
13
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Drug development and industrial pharmacy → ACNP
ISSN journal
03639045
Volume
20
Issue
9
Year of publication
1994
Pages
1699 - 1708
Database
ISI
SICI code
0363-9045(1994)20:9<1699:TIO2OD>2.0.ZU;2-E
Abstract
The influence of 2-hydroxypropyl-beta-cyclodextrin (HP beta CD) on the permeability of hydrocortisone through semi-permeable cellophane memb rane and hairless mouse skin was investigated. When the hydrocortisone concentration was kept constant and the HP beta CD concentration in a n aqueous vehicle was gradually increased the flux through the semi-pe rmeable membrane was increased until all hydrocortisone had dissolved, after that the flux decreased with increasing HP beta CD concentratio n. A maximum flux was obtained when just enough HP beta CD was used to dissolve all the drug in the aqueous vehicle.