STABILITY OF AN EXTEMPORANEOUSLY COMPOUNDED CISAPRIDE SUSPENSION

The purpose of the study was to formulate a cisapride suspension that would be stable under usual storage conditions for 3 weeks. Cisapride is a new prokinetic agent that is available as a coated tablet; occasi onally, however, patients require a liquid preparation of cisapride. C isapride was formulated with propylene glycol to enhance its solubilit y. The suspension was buffered with sodium bicarbonate to produce a pH between 6.5 and 7.5. The formulation provided a cisapride suspension that was stable at room temperature for 3 weeks.