MUTAGENICITY SCREENING OF WATER EXTRACTS FROM CRUDE DRUGS AND QUERCETIN AS MUTAGENIC COMPONENT

Authors
NOZAKA T YAMADA S HIROSE Y ISHINO M TANAKA A
Citation
T. Nozaka et al., MUTAGENICITY SCREENING OF WATER EXTRACTS FROM CRUDE DRUGS AND QUERCETIN AS MUTAGENIC COMPONENT, Eisei Kagaku, 40(1), 1994, pp. 66-70
Citations number
NO
Categorie Soggetti
Environmental Sciences",Toxicology
Journal title
Eisei Kagaku → ACNP
ISSN journal
0013273X
Volume
40
Issue
1
Year of publication
1994
Pages
66 - 70
Database
ISI
SICI code
0013-273X(1994)40:1<66:MSOWEF>2.0.ZU;2-H
Abstract
Water extracts of 41 commercial crude drugs were subjected to screenin g studies for mutagenicity by means of the reversion assay with Ames' strain TA98 and TA100 of Salmonella typhimurium. Ten of the water extr acts were found to be positive in the Ames test. In general, these obs erved mutagenicity was, however, quite weak. Among them we attempted t o isolate a major mutagenic component from Sophorae flos which was mar kedly active, and was regarded as quercetin.