Carpal tunnel syndrome is the most common focal entrapment syndrome. F
orceful repetitive activity and vibration may be important workplace r
isk factors for carpal tunnel syndrome. Although systematic study has
suggested that carpal tunnel syndrome is work-related, no clear ''dose
-response'' curve has been found between the amount or severity of wor
k and the incidence or severity of the syndrome. Nocturnal pain is a h
allmark of the syndrome, and Phalen's test, the carpal compression tes
t and the Flick test are useful indicators of the diagnosis. The most
commonly used confirmatory test is the nerve conduction study, with or
without electromyography. The primary care physician can treat many c
ases successfully with simple ergonomic modifications, splinting and s
teroid injections. Surgical therapy is reserved for recalcitrant cases
and patients with more severe nerve impingement. In addition to tradi
tional open procedures, carpal tunnel release may be performed endosco
pically.