BISMUTH MODULATION OF ANTIBIOTIC-ACTIVITY AGAINST GASTROINTESTINAL BACTERIAL PATHOGENS

Authors
DOMENICO P PARIKH D CUNHA BA
Citation
P. Domenico et al., BISMUTH MODULATION OF ANTIBIOTIC-ACTIVITY AGAINST GASTROINTESTINAL BACTERIAL PATHOGENS, Medical microbiology letters, 3(3), 1994, pp. 114-119
Citations number
NO
Categorie Soggetti
Microbiology
Journal title
Medical microbiology letters → ACNP
ISSN journal
10184627
Volume
3
Issue
3
Year of publication
1994
Pages
114 - 119
Database
ISI
SICI code
1018-4627(1994)3:3<114:BMOAAG>2.0.ZU;2-L
Abstract
Bismuth subsalicylate (BSS) antimicrobial activity was tested in combi nation with several antibiotics against enteric pathogens. BSS promote d rifampicin or gentamicin activity, yet markedly inhibited the activi ty of imipenem. Other antibiotics were not affected by BSS against ent eric pathogens. In conclusion, BSS can exhibit synergy or antagonism w ith antibiotics in vitro, which should be considered when devising com bined therapy for gastrointestinal disorders.