MEDIAN NODULE OF THE UPPER LIP - AN AUTOSOMAL-DOMINANT TRAIT

We describe a total of 18 individuals, in 3 families, with a median no dule of the upper lip. In family 1, the proposita, an 8-month-old infa nt girl, was otherwise phenotypically normal except for a median nodul e of the upper lip. The proposita's elder brother and mother, both phe notypically normal, also had the similar nodule of the upper lip. On t he mother's side, the proposita's greatgrandmother, greatgrandaunt, gr andfather, greataunt, two aunts, and one female cousin all had a media n nodule of the upper lip. In family 2, the proposita, proposita's mot her and maternal grandfather had a median nodule of the upper lip. In family 3, the proposita, proposita's father, paternal grandfather, pat ernal uncle, and cousin had a median nodule of the upper lip. Analysis of 3 families indicates that the condition is an autosomal dominant t rait. (C) 1994 Wiley-Liss, Inc.