SERUM INTERLEUKIN-6 AND C-REACTIVE PROTEIN-LEVELS CORRELATE WITH RESISTANCE TO IL-2 THERAPY AND POOR SURVIVAL IN MELANOMA PATIENTS

Authors
TARTOUR E DORVAL T MOSSERI V DENEUX L MATHIOT C BRAILLY H MONTERO F JOYEUX I POUILLART P FRIDMAN WH
Citation
E. Tartour et al., SERUM INTERLEUKIN-6 AND C-REACTIVE PROTEIN-LEVELS CORRELATE WITH RESISTANCE TO IL-2 THERAPY AND POOR SURVIVAL IN MELANOMA PATIENTS, British Journal of Cancer, 69(5), 1994, pp. 911-913
Citations number
18
Categorie Soggetti
Oncology
Journal title
British Journal of Cancer → ACNP
ISSN journal
00070920
Volume
69
Issue
5
Year of publication
1994
Pages
911 - 913
Database
ISI
SICI code
0007-0920(1994)69:5<911:SIACPC>2.0.ZU;2-5
Abstract
Interleukin 6 and C-reactive protein (CRP) were determined prior to IL -2 therapy in sera from metastatic melanoma patients. Patients with el evated serum IL-6 (> 20 pg ml(-1)) and/or CRP (> 10 mg l(-1)) levels w ere associated with resistance to IL-2 therapy. A correlation between high serum IL-6 levels and a shorter median survival was also observed .