Imaging findings from a single case of disseminated infection with Fus
arium are presented. This common fungus has been reported as a rare pa
thogen to the immunocompromised. Disseminated foci were identified on
a Tc-99m HMPAO labeled WBC study. Two foci were localized to the proxi
mal tibia using MRI. In this case, imaging was more sensitive to the e
xtent of disease than physical examination, and it also provided a mor
e precise estimate of disease progression than clinical evaluation alo
ne. Imaging offers potential to track regression and to identity early
recurrence. This is especially valuable because infection with Fusari
um tends to be indolent.