F. Rauch et al., URINARY-EXCRETION OF HYDROXY-PYRIDINIUM CROSS-LINKS OF COLLAGEN REFLECTS SKELETAL GROWTH VELOCITY IN NORMAL-CHILDREN, Experimental and clinical endocrinology, 102(2), 1994, pp. 94-97
Two new markers of bone resorption, the colla,gen cross-linking amino
acids pyridinoline (PYD) and deoxypyridinoline (DPD), were measured in
24-h urine collections from 88 healthy children (45 females, 43 males
; age 4 to 18 years) and 17 adults. Normal values for pediatric use we
re established for these parameters. Related to daily excretion of cre
atinine PYD and DPD were about 3 to 6 fold higher in the pediatric gro
ups than in adults. The collagen cross-links showed a highly significa
nt correlation to the urinary excretion of hydroxyproline (OHP): r = 0
.65 for PYD and r = 0.60 for DPD (p < 0.001). Both collagen cross-link
s and OHP excretion related to creatinine were significantly correlate
d to growth velocity (r = 0.67, 0.62 and 0.51 for PYD, DPD and OHP res
pectively; p < 0.001 in each case). PYD and DPD may be useful for the
monitoring of growth in children.