SUBSITE STUDY OF HUMAN PEPSIN IN DISEASE

Authors
BALBAA M HAMED EA ELASHWAH A SALEM O SHAMSSELDIN A
Citation
M. Balbaa et al., SUBSITE STUDY OF HUMAN PEPSIN IN DISEASE, Indian Journal of Biochemistry & Biophysics, 31(2), 1994, pp. 136-137
Citations number
16
Categorie Soggetti
Biophysics,Biology
Journal title
Indian Journal of Biochemistry & Biophysics → ACNP
ISSN journal
03011208
Volume
31
Issue
2
Year of publication
1994
Pages
136 - 137
Database
ISI
SICI code
0301-1208(1994)31:2<136:SSOHPI>2.0.ZU;2-U
Abstract
The synthetic peptides AC-Glu-Phe-Phe (NO2)-Arg-amide (peptide VP) and AC-Ile-Glu-Phe-Phe (NO2)Arg-amide (peptide VIP) are more readily hydr olyzed by human pepsin in gastric juice of patients of gastritis than those of duodenal ulcer and normal subjects. The kinetic parameters su ggest that S-3 subsite of the enzyme plays a role in the elevation of enzyme activity in gastric disease.