SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF A SERIES OF PENICILLIN-DERIVED PSEUDOSYMMETRIC INHIBITORS OF HIV-1 PROTEINASE

Authors
HUMBER DC BAMFORD MJ BETHELL RC CAMMACK N ORR DC STORER R WEINGARTEN GG WYATT PG
Citation
Dc. Humber et al., SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF A SERIES OF PENICILLIN-DERIVED PSEUDOSYMMETRIC INHIBITORS OF HIV-1 PROTEINASE, Antiviral chemistry & chemotherapy, 5(3), 1994, pp. 197-200
Citations number
14
Categorie Soggetti
Biology,"Pharmacology & Pharmacy
Journal title
Antiviral chemistry & chemotherapy → ACNP
ISSN journal
09563202
Volume
5
Issue
3
Year of publication
1994
Pages
197 - 200
Database
ISI
SICI code
0956-3202(1994)5:3<197:SASOAS>2.0.ZU;2-H
Abstract
The synthesis from penicillin G of a series of potent pseudosymmetric inhibitors 11 a-k of HIV-1 proteinase is described. The 2-pyridyl subs tituted compounds 11a and 11j showed improved antiviral activity compa red to their C-2-symmetric counterparts 3 and 4.