VASCULAR REACTIVITY TO ANGIOTENSIN-II IS SELECTIVELY ENHANCED IN THE KIDNEYS OF SPONTANEOUSLY HYPERTENSIVE RATS

The two aims of the present study were to: 1) explore the hypothesis t hat the kidneys of spontaneously hypertensive rats (SHR) are more resp onsive to angiotensin II (Ang II) than are the kidneys of normotensive Wistar Kyoto rats (WKY) and 2) determine whether other vascular beds of SHR exhibit enhanced responsiveness to Ang II, relative to WKY. SHR and WKY received captopril from 4 weeks of age until the time of the experiment to prevent vascular alterations secondary to hypertension. Blood pressure, heart rate, cardiac output and blood flow through the superior mesenteric artery, left renal artery, lower abdominal aorta a nd right carotid artery were monitored in anesthetized SHR and WKY dur ing acute i.v. administration of Ang II at doses of 0, 3, 10, 30, 100 and 300 ng kg(-1) min(-1). The heart rate and cardiac output were not significantly affected but the blood pressure was increased to a simil ar extent in both strains during the Ang II infusion. Hindquarter (aor tic) resistance was unaffected by Ang II in both strains. Carotid resi stance was slightly increased by the peptide to a similar magnitude in SHR and WKY. The renal and mesenteric vasculature of both strains wer e highly sensitive to Ang II, with significant dose-related increases in resistance during the infusion. The magnitude of the mesenteric res ponse was not different between SHR and WKY. However, the renal vascul ar response to Ang II was significantly greater in SHR than in WKY. In conclusion, the enhanced responsiveness to i.v. Ang II occurred selec tively in the kidney of SHR and not in the other vessels examined.