THE ASSOCIATION BETWEEN AGE AND BONE-MINERAL DENSITY IN MEN AND WOMENAGED 55 YEARS AND OVER - THE ROTTERDAM STUDY

In this cross-sectional study, bone mineral density (BMD) measurements were performed in 1762 ambulatory subjects (678 men and 1084 women) a ged 55 years and over from the Rotterdam Study, a population based stu dy of diseases in the elderly. BMD measurements of the proximal femur and lumbar spine were performed using dual energy X-ray absorptiometry . No age-related decline in BMD could be observed in the lumbar spine. Yearly percentage BMD reduction in women and men was -0.6% and -0.3% in the femoral neck, -0.8% and -0.5% in the Ward's triangle, and -0.4% and -0.3% in the trochanter, respectively. Late menopause was associa ted with high BMD in Ward's triangle and lumbar spine. We conclude tha t: (1) accurate assessment of age-related bone reduction in the spine is impossible from cross-sectional studies since BMD measurements in t he elderly may be influenced by spinal osteoarthritis; and (2) the rat e of age-related bone reduction in the femoral neck appears to be appr oximately two times higher in women than in men.