FAMILIAL ANALYSIS OF CHROMOSOME-ABERRATIO NS IN PATIENTS WITH T-CELLULAR LYMPHOMAS OF VARIOUS MALIGNANCY DEGREES

Qualitative and quantitative analysis of chromosome aberrations and th eir correlations with oncogen localization sites was carried out in 7 patients with T-cellular malignant lymphomas of the skin of various ma lignancy degree, in 3 families of probands with non-Hodgkin's lymphoma s (7 relatives of the first kinship degree), and in 7 controls. Two va riants of lymphocyte cultivation were used: in medium 199 and in Eagle 's medium with afidicolin. A total of 200 to 300 metaphases were analy zed. XA incidence was higher in the patients than in normal subjects, and dicentric and annular chromosomes were more frequently seen. In tw o patients cellular clones with an extra chromosome were found. XA inc idence correlated with the process malignancy. Besides a variety of fr agility sites, many common sites were found in patients with T-cellula r malignant lymphomas of all malignancy degrees. Many fragility sites identified in T-cellular lymphoma patients coincided with oncogen loca lization sites in the relatives of 4 subjects with a high XA incidence . Medicogenetic counselling of relatives of patients with T-cellular m alignant lymphomas of the skin are necessary to timely detect various oncologic diseases.