TIME-COURSE OF PARACLINICAL PARAMETERS IN PATIENTS WITH T-CELLULAR LYMPHOMAS OF THE SKIN WITH REACTIVE MONOCYTOSIS TREATED BY POLYCHEMOHORMONOTHERAPY INCLUDING LEUKIN-FERON

Forty-three patients with T-cellular malignant lymphomas of the skin o f various malignancy degrees and 23 healthy donors were examined. Poly chemohormonotherapy with leukinferon was conducive to a reduction of 0 cell counts, pathologic clone cells in the skin and blood, and to nor malization of T, T active, and B cells with recovery of their normal r elationships, as well as to normalization of gamma-interferon producti on and monocyte and lymphocyte capillary to venous blood ratio (CVR) i n patients both with and without reactive monocytosis. Normalization o f the regularities characteristic of lymphocytic CVR (dependence on ma lignancy degree) was observed in analysis of monocyte CVR in patients with T-cellular malignant lymphomas of the skin without reactive monoc ytosis or concomitant inflammatory diseases. The maximal reduction of monocyte and lymphocyte CVR was seen in the majority of patients admin istered steroids for a long time, both with and without reactive monoc ytosis. This was parallelled by a reduction of the absolute count of b lood monocytes and of the histiocytic component of the infiltrate both in the upper and lower half of the derma with a trend to normalizatio n of the lymphocyte/histiocyte ratio, Results of a simple measurement of monocyte to lymphocyte absolute counts in capillary and venous bloo d, changed in concomitant inflammatory diseases and in the presence of reactive monocytosis may be indicative of immunity status normalizati on in patients with T-cellular lymphomas in the course of differentiat ed therapy with leukinferon immunocorrection, including cases with com plications of polychemohormonotherapy. Reduction of steroid doses in t he course of therapy including leukinferon is conducive to normalizati on of monocyte and lymphocyte CVR.