HYMENOPTERA SENSITIVITY OCCURRING IN FAMILIES

A total of 248 patients with systemic reactions to Hymenoptera envenom ation were studied. There were 138 adults and 110 children. Twenty-eig ht of these 248 (11.3%) had family members with histories consistent w ith Hymenoptera anaphylaxis. These included five mothers and sons, two sister pairs, three pairs of sister-brother, one pair brother-brother , and one pair father-daughter. In one extended family, a father, moth er, son, and mother's sister had Hymenoptera sensitivity. Ninety-six c onsecutive allergic patients without Hymenoptera sensitivity served as controls, and of these, 3.1% had family members with Hymenoptera sens itivity. The occurrence of Hymenoptera sensitivity in families of pati ents with Hymenoptera sensitivity is statistically different from our controls (11.3% vs 3.1%, p = 0.0195). There appears to be a hereditary aspect for Hymenoptera sting sensitivity.