APPLICATION OF YEAST-CATALYZED REDUCTIONS TO SYNTHESIS OF (2R,3S)-PHENYLISOSERINE

Authors
KEARNS J KAYSER MM
Citation
J. Kearns et Mm. Kayser, APPLICATION OF YEAST-CATALYZED REDUCTIONS TO SYNTHESIS OF (2R,3S)-PHENYLISOSERINE, Tetrahedron letters, 35(18), 1994, pp. 2845-2848
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
18
Year of publication
1994
Pages
2845 - 2848
Database
ISI
SICI code
0040-4039(1994)35:18<2845:AOYRTS>2.0.ZU;2-7
Abstract
A simple synthesis of (2R,3S)-phenylisoserine, a precursor of the C-13 side chain of Taxol(R)(paclitaxel), utilising yeast-catalyzed reducti on to generate a second chiral centre is reported. This short enantios elective series of transformations can be readily adapted to large sca le production of a variety of N-substituted paclitaxel analogues.