THE GLYCINE-RICH SEQUENCE OF PROTEIN-KINASES - A MULTIFUNCTIONAL ELEMENT

Evolution favours the use of glycine-rich loops for nucleotide binding in proteins. In the large family of protein kinases, the catalytic do main of which has one of the highest degrees of conservation among all known proteins, the structure of the nucleotide-binding site differs from classical folds. We are now beginning to understand the multiple functional roles of the glycine-rich sequence in protein kinases and s ome of the structural constraints leading to its conservation.