INHIBITORS OF ACYL-COA-CHOLESTEROL ACYLTRANSFERASE .10. IMIDAZOLIDINONES AND PYRAZOLONES AS NOVEL ACAT INHIBITORS - CHEMISTRY AND BIOLOGICAL-ACTIVITY

Authors
AUGELLISZAFRAN CE ROTH BD ESSENBURG A HAMELEHLE KL KRAUSE BR STANFIELD RL
Citation
Ce. Augelliszafran et al., INHIBITORS OF ACYL-COA-CHOLESTEROL ACYLTRANSFERASE .10. IMIDAZOLIDINONES AND PYRAZOLONES AS NOVEL ACAT INHIBITORS - CHEMISTRY AND BIOLOGICAL-ACTIVITY, Bioorganic & medicinal chemistry letters, 4(9), 1994, pp. 1095-1100
Citations number
25
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
9
Year of publication
1994
Pages
1095 - 1100
Database
ISI
SICI code
0960-894X(1994)4:9<1095:IOAA.I>2.0.ZU;2-E
Abstract
Our continued interest in inhibitors of acyl-coenzyme A:cholesterol ac yltransferase (ACAT) has led us to study a series of imidazolidinones (I) and a series of pyrazolones (II), two systems structurally distinc t from our other reported series. The synthesis and biological activit y of I and II are reported.