L. Derobertis et al., SYNTHESIS OF NEW OLIGOSACCHARIDYL-THIO-BETA-CYCLODEXTRINS (CDS) - A NOVEL FAMILY OF POTENT DRUG-TARGETING VECTORS, Bioorganic & medicinal chemistry letters, 4(9), 1994, pp. 1127-1130
Six potential carriers incorporating one or more thio-D-galactosyl res
idue(s) linked to beta-cylodextrin as complexing tool, were synthesize
d and evaluated in vitro for their specific recognition towards a cell
wall galactose specific lectin (KbCWL). The inhibition of yeast flocc
ulation by the compounds 5 -10 was compared to reference compounds as,
p-nitrophenyl-galactose or disaccharides containing an alpha or beta-
galactose non reducing terminal unit. Among the tested molecules, the
heptakis galactosyl-CD derivatives were found the most efficient compo
unds.