SYNTHESIS OF NEW OLIGOSACCHARIDYL-THIO-BETA-CYCLODEXTRINS (CDS) - A NOVEL FAMILY OF POTENT DRUG-TARGETING VECTORS

Authors
DEROBERTIS L LANCELONPIN C DRIGUEZ H ATTIOUI F BONALY R MARSURA A
Citation
L. Derobertis et al., SYNTHESIS OF NEW OLIGOSACCHARIDYL-THIO-BETA-CYCLODEXTRINS (CDS) - A NOVEL FAMILY OF POTENT DRUG-TARGETING VECTORS, Bioorganic & medicinal chemistry letters, 4(9), 1994, pp. 1127-1130
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
9
Year of publication
1994
Pages
1127 - 1130
Database
ISI
SICI code
0960-894X(1994)4:9<1127:SONO(->2.0.ZU;2-O
Abstract
Six potential carriers incorporating one or more thio-D-galactosyl res idue(s) linked to beta-cylodextrin as complexing tool, were synthesize d and evaluated in vitro for their specific recognition towards a cell wall galactose specific lectin (KbCWL). The inhibition of yeast flocc ulation by the compounds 5 -10 was compared to reference compounds as, p-nitrophenyl-galactose or disaccharides containing an alpha or beta- galactose non reducing terminal unit. Among the tested molecules, the heptakis galactosyl-CD derivatives were found the most efficient compo unds.