2,3,6-SUBSTITUTED QUINAZOLINONES AS ANGIOTENSIN-II RECEPTOR ANTAGONISTS

Authors
LEVIN JI VENKATESAN AM CHAN PS BAKER JS FRANCISCO G BAILEY T VICE G KATOCS A LAI F COUPET J
Citation
Ji. Levin et al., 2,3,6-SUBSTITUTED QUINAZOLINONES AS ANGIOTENSIN-II RECEPTOR ANTAGONISTS, Bioorganic & medicinal chemistry letters, 4(9), 1994, pp. 1135-1140
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
9
Year of publication
1994
Pages
1135 - 1140
Database
ISI
SICI code
0960-894X(1994)4:9<1135:2QAARA>2.0.ZU;2-0
Abstract
The synthesis and biological evaluation of a series of 2,3,6-substitut ed 4(3H)quinazolinones is described. One of these compounds, CL329,167 , was found to be a potent, orally active, competitive angiotensin II receptor antagonist with a long duration of action.