SYNTHESIS OF CYCLIC OLIGODEOXYRIBONUCLEOT IDES WITH NON-NUCLEOTIDE INSERTS

Authors
ORETSKAYA TS DOLINNAYA NG MERENKOVA IN KRYNETSKAYA NF ROMANOVA EA VOLKOV EM BLUMENFELD M VASSEUR M SHABAROVA ZA
Citation
Ts. Oretskaya et al., SYNTHESIS OF CYCLIC OLIGODEOXYRIBONUCLEOT IDES WITH NON-NUCLEOTIDE INSERTS, Bioorganiceskaa himia, 20(1), 1994, pp. 63-66
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Bioorganiceskaa himia → ACNP
ISSN journal
01323423
Volume
20
Issue
1
Year of publication
1994
Pages
63 - 66
Database
ISI
SICI code
0132-3423(1994)20:1<63:SOCOIW>2.0.ZU;2-S
Abstract
An effective method for the oligonucleotide cyclization using BrCN-ind uced chemical ligation was developed. The novel idea to incorporate no n-nucleotide inserts makes the process of cyclizations independent of the inner secondary structure of the linear precursor. An set of assay s were developed to confirm the cyclic structure of the compounds obta ined.