THE EXPRESSION OF MDM2 AND P53 PROTEIN BREAST-CARCINOMA

We studied the expression of MDM2 protein and p53 protein in 67 cases of the breast carcinoma. The result demonstrated no significant relati onship between the MDM2 protein expression and any of the clinicopatho logical parameters except for the estrogen receptor status (p=0.033). Furthermore, in p53 protein negative cases, there was a significant re lationship between MDM2 protein expression and the ER status (p=0.027) . This study showed the expression of ER to be associated with MDM2 pr otein in p53 protein negative breast carcinoma. These results thus sug gested that an investigation of both p53 and MDM2 gene alteration reve aled precise information regarding breast carcinoma.