CHEMOTHERAPY OF HUMAN ALPHA-FETOPROTEIN-PRODUCING GASTRIC CARCINOMAS GROWN IN NUDE-MICE

We have examined the effects of chemotherapeutic drugs on tumor growth and metastasis of human alpha-fetoprotein-producing gastric carcinoma (AFPGC) xenografts growing in nude mice. These xenografts consisted o f 3 hepatoid adenocarcinomas and 2 non-hepatoid, poorly differentiated adenocarcinomas. Mitomycin C and cisplatin inhibited the tumor growth and liver metastasis of hepatoid adenocarcinomas in nude mice. 5-fluo rouracil also inhibited the growth of hepatoid adenocarcinomas but did not exhibit a significant antimetastatic action. Doxorubicin was effe ctive only against non-hepatoid adenocarcinomas. These results indicat e that chemotherapeutic drugs for AFPGC should be used according to th e subtype of the tumor.