A LAMELLAR LIQUID-CRYSTAL WITH FOSINOPRIL SODIUM

The location and conformation of fosinopril sodium (FS) in a lamellar liquid crystal of water, sodium dodecyl sulfate, and decanol was studi ed by low-angle X-ray diffraction. The result showed the FS molecule t o be located within the amphiphilic part of the liquid crystalline str ucture with the polar parts anchored at the water/polar part interface . An area per molecule in the range of 95-100 Angstrom(2) showed not o nly the polar groups but also the benzene ring to be located at this i nterface.