POTENT INHIBITORS OF HISTAMINE-RELEASE - POLYHYDROXYLATED STEROLS FROM THE OKINAWAN SOFT CORAL SINULARIA-ABRUPTA

Authors
SHOJI N UMEYAMA A TAKEI M ARIHARA S
Citation
N. Shoji et al., POTENT INHIBITORS OF HISTAMINE-RELEASE - POLYHYDROXYLATED STEROLS FROM THE OKINAWAN SOFT CORAL SINULARIA-ABRUPTA, Journal of pharmaceutical sciences, 83(5), 1994, pp. 761-762
Citations number
11
Categorie Soggetti
Chemistry,"Pharmacology & Pharmacy
Journal title
Journal of pharmaceutical sciences → ACNP
ISSN journal
00223549
Volume
83
Issue
5
Year of publication
1994
Pages
761 - 762
Database
ISI
SICI code
0022-3549(1994)83:5<761:PIOH-P>2.0.ZU;2-K
Abstract
A new polyhydroxylated Steroid (24-methylene-1 alpha,3 beta, 11 alpha- trihydroxycholest-5-ene-18-oic acid-3-acetate, 1) and known related co mpounds (2-4) from the soft coral Sinularia abrupta have potently inhi bited histamine release from rat peritoneal mast cells induced by anti -immunoglobulin E. The inhibitory effect of 1 was similar to 6500 time s stronger than that of disodium cromoglycate, a well-known antiallerg ic drug.