A NOVEL ONE-STEP APPROACH TO SMALL-SCALE LABELING OF ORGANIC-COMPOUNDS WITH HYDROGEN ISOTOPES

Authors
MALIK S KENNY M DOSS G JOHN V
Citation
S. Malik et al., A NOVEL ONE-STEP APPROACH TO SMALL-SCALE LABELING OF ORGANIC-COMPOUNDS WITH HYDROGEN ISOTOPES, Journal of labelled compounds & radiopharmaceuticals, 34(5), 1994, pp. 471-473
Citations number
5
Categorie Soggetti
Chemistry Analytical","Pharmacology & Pharmacy
Journal title
Journal of labelled compounds & radiopharmaceuticals → ACNP
ISSN journal
03624803
Volume
34
Issue
5
Year of publication
1994
Pages
471 - 473
Database
ISI
SICI code
0362-4803(1994)34:5<471:ANOATS>2.0.ZU;2-F
Abstract
A rapid method to generate tritium gas for small scale labeling is des cribed. Tritium labelled sodium borohydride is used with cobalt (II) c hloride to generate isotopic hydrogen gas. The reaction was carried ou t in a closed vessel and three different compounds were concurrently l abelled. This simple and inexpensive method can be applied to a broad range of molecules and does not require any special set up.