ANALYSIS OF DIASTEREOISOMER IMPURITIES IN CHIRAL PHARMACEUTICAL COMPOUNDS BY CAPILLARY ELECTROPHORESIS

Micellar electrokinetic capillary chromatography (MECC) has been appli ed to the separation and analysis of diastereoisomer impurities in chi ral pharmaceutical compounds. Differences in separation mechanism and selectivity make MECC useful as an alternative method to HPLC for anal ysis of these synthetic impurities. Advantages of MECC include high ef ficiency separations and low consumption of sample and solvents. Water soluble and insoluble pharmaceutical compounds are used to illustrate the separation characteristics and quantitative capabilities of this versatile new analytical technique.