ADVERSE-EFFECTS OF POLYETHYLENE-GLYCOL AND PHENYTOIN ON THE RECTAL MUCOSA OF THE RAT

Authors
PIENAAR EW KRIEK NPJ BONESCHANS B KOELEMAN HA
Citation
Ew. Pienaar et al., ADVERSE-EFFECTS OF POLYETHYLENE-GLYCOL AND PHENYTOIN ON THE RECTAL MUCOSA OF THE RAT, Drug development and industrial pharmacy, 20(8), 1994, pp. 1493-1502
Citations number
3
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Drug development and industrial pharmacy → ACNP
ISSN journal
03639045
Volume
20
Issue
8
Year of publication
1994
Pages
1493 - 1502
Database
ISI
SICI code
0363-9045(1994)20:8<1493:AOPAPO>2.0.ZU;2-4
Abstract
The effects of polyethylene glycol (used as suppository base), a surfa ctant (Polyoxyl 59 stearate - Myrj 59(R)) and phenytoin on the rectal mucosa of the rat were investigated. Four different types of effects w ere observed in the 52 rats treated with the various polyethylene glyc ol, surfactant and phenytoin combinations. Polyethylene glycol had a d efinite necrotic effect on the rectal mucosa of the rat. This adverse effect was more pronounced when phenytoin and polyoxyl 59 stearate wer e combined with the polyethylene glycol.