R. Debree et al., CLINICAL IMAGING OF HEAD AND NECK-CANCER WITH TC-99M-LABELED MONOCLONAL-ANTIBODY E48 IGG OR F(AB')(2), The Journal of nuclear medicine, 35(5), 1994, pp. 775-783
Methods: In 32 patients who were suspected of having a neck lymph node
metastasis from a histologically proven squamous-cell carcinoma of th
e head and neck (HNSCC), the diagnostic value of Tc-99m-labeled (750 M
Bq) monoclonal antibody (1-2 mg) E48 IgG (n = 17) and its F(ab')(2) fr
agment (n = 15) was evaluated and compared. Preoperative findings on l
ymph node status obtained by radioimmunoscintigraphy (RIS), computeriz
ed tomography (CT), magnetic resonance imaging (MRI) and palpation wer
e defined per side (left and/or right side of the neck) as well as per
lymph node level (I through V) and compared to the histopathological
outcome of the neck dissection specimen.