DAPIPRAZOLE CLINICAL-EFFICIENCY FOR COUNTERACTING TROPICAMIDE 1-PERCENT

We evaluated the clinical usefulness of dapiprazole in reversing the e ffects of tropicamide 1.0%. Our study was random, masked with placebo, and used one eye of each subject as a control. Thirty subjects were g iven dapiprazole as directed by the manufacturer 30 min after being di lated by one drop each of proparacaine 0.5%, tropicamide 1.0%, and the n 5 min later another drop of tropicamide 1.0%. Pupil diameter, amplit ude of accommodation, conjunctival injection, and intraocular pressure were evaluated. Each of these variables was measured: (1) before inst illation of the diagnostic agents; (2) before the instillation of dapi prazole; and (3) at 30, 60, 120, and 180 min after the final instillat ion of dapiprazole. The average pupillary recovery time for dapiprazol e-treated eyes was significantly less than for nontreated eyes. Accomm odation also showed faster recovery. Comfortable reading ability retur ned after approximately 43 min with dapiprazole vs. 66 min without dap iprazole. All of our subjects exhibited conjunctival hyperemia after t he administration of dapiprazole. This persisted throughout the 180 mi n observation period after its administration.