In a double-blind study 238 patients were examined with lumbar myelogr
aphy using iotrolan or iohexol in randomized sequence in order to eval
uate the image quality, the safety and tolerance of iotrolan by monito
ring the adverse effects with special attention to late reactions. The
re were no serious complications. On the first day 28 patients (24%) h
ad headache after iotrolan and 41 (34%) after iohexol. This difference
was not significant, and these frequencies are similiar to those foun
d after spinal puncture alone. The second most frequent side effect wa
s neck pain; the duration of neck pain were significantly longer after
myelography with iohexol than with iotrolan. There was a significantl
y higher frequency of adverse effects in females the first 24 hours, b
ut during examination and on days 2 to 4 there were no differences bet
ween males and females. Anamnestic information or myelographic diagnos
is could not predict which patients would have side effects. The image
quality was excellent or good in all examinations but one. It is conc
luded that iotrolan is a safe contrast medium well suited for lumbar m
yelography.